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TMJ

(60) Immunohistochemical Expression of GRP78 in Temporomandibular Joint Dysfunction

Thursday, September 12, 2024
2:30 PM – 4:00 PM EDT
Disclosure(s):
Olivia Kraft, BS: No financial relationships to disclose
Samuel Zammuto, BS: No financial relationships to disclose
Abstract:

Objectives: GRP78 is a binding immunoglobulin protein (BiP) that is involved with the folding and processing of proteins during the unfolded protein response (UBR). It has become a frequent area of study within cancer and cell proliferation research. The purpose of this study is to gain insight into how GRP78 expression relates to temporomandibular joint dysfunction (TMD).

Methods: Twenty-two human TMJ disc samples went through immunohistochemical staining for GRP78 and were evaluated for staining intensity. The samples consisted of 12 patients with anterior disc displacement with reduction (ADDwR), 6 with anterior disc displacement without reduction (ADDwoR), and 4 controls.

Results: There was a statistically significant difference in staining intensity between the control and experimental groups. GRP78 was found to be present in larger amounts in both experimental groups (P < .0001). This data suggests the importance of GRP78 in the progression of TMD.

Conclusion: GRP78 expression is likely involved in the pathogenesis of TMD in some way, as there is a statistically significant difference in expression between discs affected by TMD and those without.

Intensity of GRP78 Expression